A sleeping pill prescribed to thousands of patients can increase the risk of heart attacks by up to 50 per cent, according to scientists.
Research carried out among heart attack victims found that numbers were higher among those who had taken zolpidem tablets, prescribed in the UK under the name Stilnoct and in the US as Ambien.
Scientists have linked taking zolpidem to an increased threat of heart attacks, and believe that taking the equivalent of 60 of the pills can increase the risk by as much as 50per cent.
Risk: A study carried out among heart attack victims found that numbers were higher among those who had taken zolpidem tablets
Even taking just four pills with a dose of 35 miligrams per year increases the risk of a life-threatening cardiac episode by 20per cent.
The study, which was carried out by experts at the China Medical University in Taiwan, is the first to link zolpidem with cardiovascular problems.
Drug manufacturers Sanofi Inc have refuted the finding and said there are no known adverse cardiac reactions to zolpidem.
Experts can not be completely sure that the pills are responsible for heart problems.
However, scientists, who presented their findings at the world’s biggest cardiology conference in Dallas, Texas, say further and wider-reaching investigations into possible side effects of the drug are required following the study of more than 5,000 people.
Scientists who compared 5,000 heart attack victims with 20,000 healthy adults claimed there was a higher rate of heart attacks among those who took zolpidem.
The findings, revealed at the annual meeting of the American Heart Association, showed that even taking the pills sporadically can increase the risk of suffering a heart attack.
'The risk of an acute myocardial infarction (heart attack) was greatly increased with zolpidem exposure,' the report said, according to the Daily Express.
Medication: Around five million people in Britain are prescribed z-hypnotics, including zolpidem, for insomnia every year
As part of a separate study the China Medical University scientists found that taking the equivalent of a 10mg zolpidem tablet every week can double the risk of a patient suffering a damaged aorta blood vessel.
According to the scientists the medication can increase the threat of an aortic dissection, where the vital aorta blood vessel is torn with potentially fatal results as it can cause internal bleeding.
In a statement Sanofi Inc said that that known adverse reactions to the drug did not include acute myocardial infarction or aortic dissection.
It said: 'We stand behind the substantial body of clinical data demonstrating the safety and efficacy of zolpidem, which was first approved in France in June 1987, amounting to 26 years of real-world use and 24 billion nights of patient therapy worldwide.'
Around five million people in Britain are prescribed z-hypnotics, including zolpidem, for insomnia every year.
However, there have been an increasing number of fears over their safety and it is recommended that patients should take the lowest dose possible for no more than four weeks.
In 2012, the US Food and Drug Administration said that the recommended dosages of zolpidem should be halved to to five milligrams because of concerns that the medication can remain in the bloodstream for longer than initially thought.
An unrelated study carried out last year showed increased rates of cancer-related deaths among people taking all varieties of sleeping pills, not just z-hypnotics.
Read more: http://www.dailymail.co.uk/health/article-2535661/Scientists-say-sleeping-pill-zolpidem-increase-risk-heart-attacks-half.html#ixzz2ppDtQgs5
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