Thousands of men suffer needlessly as prostate cancer surgery is often 'a waste of time'

Thousands of men are undergoing debilitating surgery for prostate cancer which may be needless, claim scientists.

They say that in many cases the tumours are growing so slowly they do not need to be treated.

A major study has shown that survival rates of men who had surgery were hardly any higher than patients whose doctors essentially did nothing.

Cancer: A survey by Everyman shows seventy-three per cent of men didn't know the top three risk factors for prostate cancer, despite it being the most common cancer in men

At present men diagnosed with the illness are offered surgery to remove the prostate gland, known as a ‘radical prostatectomy’.  

The operation often has distressing side effects and more than half of men are left impotent and one in ten incontinent.

 

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Now early results from the Prostate Intervention Versus Observation Trial (PIVOT) suggest that in many cases surgery is pointless.

The study began in 1994 involving 731 men with prostate cancer whose average age was 68. 

They were monitored over the next 12 years and some had surgery while others underwent ‘watchful waiting’ which means their doctors did not treat them.

The results – presented at a meeting of the European Association of Urology – show that on average the men undergoing surgery were just 3 per cent more likely to have survived than the ‘watchful waiting’ group.  

However surgery was found to increase the survival chances of men with the most serious forms of prostate cancer, the European Association of Urology was told.

Study author Dr Timothy Wilt, of the University of Minnesota, concluded that surgery did not ‘significantly reduce prostate cancer mortality’. 

Around 37,000 men are diagnosed with prostate cancer in Britain every year and another 10,000 die.

Read more: http://www.dailymail.co.uk/health/article-2137135/Thousands-men-suffer-needlessly-prostate-cancer-surgery-waste-time.html#ixzz1tUCCZibr

What Is Prostate Cancer?

Prostate cancer develops in a man's prostate, the walnut-sized gland just below the bladder that produces some of the fluid in semen. It's the most common cancer in men after skin cancer.  Prostate cancer often grows very slowly and may not cause significant harm.  But some types are more aggressive and can spread quickly without treatment.

Genetic mutation tied to inherited prostate cancer

Scientists say they've identified the first genetic mutation with a major effect on the risk of prostate cancer that runs in families and strikes men early, by age 55.

The mutation accounts for only about 1 percent of all prostate cancers. But studying it might help scientists understand the disease in general and find better treatments.

More than 240,000 men are expected to be diagnosed with prostate cancer in the United States this year. Most cases are sporadic rather than inherited, and on average they are diagnosed around age 70.

The work is reported in Thursday's issue of the New England Journal of Medicine. The researchers said inheriting the mutation raises the risk of prostate cancer by 10 times or more.

Read more: http://www.foxnews.com/health/2012/01/12/genetic-mutation-tied-to-inherited-prostate-cancer/#ixzz1jHD3sg7C

Milk Intake in Teens Tied to Later Prostate Cancer

Older Icelandic men who remember chugging a lot of milk in their teens are three times as likely to be diagnosed with advanced prostate cancer as more-moderate milk drinkers, researchers have found.

That makes them wonder whether the years around puberty, during which the prostate matures, could be a time of heightened vulnerability for the gland.

"We believe that our data are indeed solid and provide important evidence for the role of adolescence as a 'sensitive period' for prostate cancer development," Johanna Torfadottir, a nutrition scientist and a graduate student at the University of Iceland, told Reuters Health by email.

"However, we remain cautious in our interpretation," she added. "Causal inferences are not made on one study alone, thus more studies are needed to confirm our findings and also to explore possible mechanism behind this association."

So far, she added, the two studies on prostate cancer and milk intake in adolescents have come to mixed conclusions -- one found milk lovers seemed to be somewhat protected against the disease, while the other found no link at all.

But both studies were small and couldn't distinguish between advanced and early-stage tumors, Torfadottir said.

By contrast, Iceland offers the perfect "natural experiment," she and her colleagues write in the American Journal of Epidemiology.

The country had little infrastructure in the early part of the 20th century, so people in rural areas tended to live off the land. That included lots of milk from farm animals in central regions of the island, whereas the drink was scarce in seaside villages.

For their study, the researchers used data from more than 2,200 men born between 1907 and 1937. These men had been part of a medical study started in the 1960s and, in the early 2000s, had answered questions about their diet in early and mid-life as part of another study.

Among 463 men who recalled drinking milk less than once a day in their teens, one percent developed advanced prostate cancer or died of the disease over a quarter century of follow-up.

That figure was three percent among the more than 1,800 men who said they drank milk at least daily in adolescence.

The gap couldn't be explained by how often people had gone to the doctor for check-ups, their education or other foods they ate, such as fish or meat.

How much milk men drank had no connection to their risk of early-stage tumors, however. And intake in midlife -- the age group most other studies have focused on -- didn't seem to matter either.

Torfadottir said there are several physiological mechanisms that might, in principle, explain the link between she found. But at this point, all of them remain speculative.

"From these data alone we cannot recommend that teenage boys should chance their dietary habits," she said. "We are only looking at the risk of one disease, prostate cancer, and obviously risks of other conditions, e.g. bone health, need to be considered."

PREMATURE TO SAY 'CAUSES'

Dr. Matthew Cooperberg, a urologist at the University of California, San Francisco, agreed.

"It would be premature to say that drinking milk causes prostate cancer," he told Reuters Health. "You can talk about association, but it is hard to prove causality."

He added that people shouldn't be wary of drinking milk.

"There are plenty of health benefits from drinking milk in adolescence," Cooperberg said.

Read more: http://www.foxnews.com/health/2011/12/30/milk-intake-in-teens-tied-to-later-prostate-cancer/#ixzz1i2YOnXYb