- Women who fail to take tamoxifen for the full five years are more likely to see their cancer return and to suffer an early death
- The drug can cause side effects including hot flushes, joint pain and fatigue
- Those who don't stick to their drug regime cost an extra £6,000 on average
- They also lose an average of 13 months reasonable quality of life
By EMMA INNES
More than 400 lives and £30 million a year could be saved if breast cancer patients took their full course of drugs, according to research.
Women who fail to take tamoxifen for the full five years have a higher chance of their cancer coming back and of suffering an early death.
A new study shows patients who do not adhere to their drug regime cost an extra £5,970 on average due to more hospital admissions and needing other medicines.
More than 400 lives and £30 million a year could be saved if breast cancer patients took their full course of drugs, according to research
They also lose an average of 13 months of reasonable quality of life from not taking the once-a-day drug.
Supporting women to take their full course of tamoxifen could save more than 400 lives every year and free up almost £30 million a year - the equivalent of 20 radiotherapy machines.
Colin McCowan, from the University of Glasgow, and his team analysed prescription records for 1,263 women with breast cancer to see how often they took tamoxifen and for how long.
Women who collected fewer than 80 per cent of their prescriptions were classed as having low adherence to the treatment. The findings showed 434 lives a year could be saved, alongside millions of pounds, if women took the drug for five years.
Writing in the British Journal of Cancer (BJC), the team said: ‘Patients with low adherence have shorter time to recurrence, increased medical costs and worse quality of life.
‘Interventions that encourage patients to continue taking their treatment on a daily basis for the recommended five-year period may be highly cost-effective.’
Women who fail to take tamoxifen for the full five years have a higher chance of their cancer coming back
Around 13,000 women a year are prescribed a five-year course of tamoxifen, usually after surgery, radiotherapy and any chemotherapy.
Side effects include hot flushes, joint pain, fatigue, weight gain and sweats. Rarer side effects include blood clots.
The Breast Cancer Campaign estimates that 5,000 of the 13,000 women prescribed tamoxifen every year fail to complete the course.
Dr McCowan said: ‘High adherence to tamoxifen would seem to benefit both the patient and the NHS.
‘We want to raise awareness among healthcare professionals that this is a real issue and that women need help and the correct advice to ensure they have the best possible chance of living beyond breast cancer.
‘We do know that side effects of this treatment are an issue and we are currently analysing interviews with women to investigate reasons why they do or don’t take their medication and other issues around adherence.
‘We hope to use these findings to develop interventions to help women and the NHS to get the most from the life-saving drugs that we already have.’
In June, it was announced that thousands of women with a family history of breast cancer would be offered tamoxifen to help prevent the disease.
The National Institute for Health and Care Excellence (Nice) said tamoxifen taken daily for five years can cut breast cancer risk by 40 per cent in these women.
Baroness Delyth Morgan, chief executive of Breast Cancer Campaign, which funded the new study, said: ‘Tamoxifen is one of the most effective treatments for breast cancer when taken as prescribed but sadly some women find it intolerable to take the full five-year course and risk recurrence of their disease.
‘This study is a timely reminder that it’s so important that women are given support to continue taking their tamoxifen so that they have the best possible chance to outlive breast cancer.’
TAKING TAMOXIFEN LEFT ME CLOSE TO THE EDGE
Carly Gibson has stopped taking tamoxifen after suffering side-effects
Carly Gibson was prescribed tamoxifen after being diagnosed with breast cancer and undergoing a lumpectomy and radiotherapy.
But only days after first taking the medication Mrs Gibson, who lives with her husband Chris and their two children in Wotton-under-Edge, Gloucestershire, began to feel unwell.
The 37-year-old said: ‘I started having hot flushes and night sweats, and a strange feeling of being cold inside.
'I was also really emotional and would walk around crying.’
Mrs Gibson, who was diagnosed at 29, stopped taking the drug two years later when she met her future husband.
They wanted to start a family, and the drug should not be taken during pregnancy.
She later gave birth to Lydia, now four, followed by Rowan, now three.
When she began taking tamoxifen again the side effects returned with a vengeance, so she decided to stop – against doctors’ wishes.
She said: ‘The worst thing was how emotional I felt — I was close to the edge at times.
'I decided my sanity and my quality of life with Chris, Lydia and Rowan was more important.’
Read more: http://www.dailymail.co.uk/health/article-2410042/Intolerable-breast-cancer-drug-causes-5-000-women-quit-medication--leading-400-deaths-year.html#ixzz2eMGG2Jp2
Follow us: @MailOnline on Twitter | DailyMail on Facebook
