Monday, November 25, 2013

Scientists hail breakthrough arthritis injection which slows down the condition and improves mobility

  • Sarilumab eases crippling symptoms of rheumatoid arthritis, a study found
  • Patients were more mobile and suffered less inflammation to joints
  • Treatment also slows down progression of the incurable condition




  • Arthritis sufferers have been given new hope following the success of a drug that appears to ease the crippling symptoms of the disease. 
    Patients who took Sarilumab were more mobile and suffered less inflammation to their joints, a study found.
    The new treatment - involving an injection once a fortnight - also slowed progression of the incurable disease. 
    Hope: Patients who took Sarilumab found they were more mobile and suffered less inflammation to their joints
    Hope: Patients who took Sarilumab found they were more mobile and suffered less inflammation to their joints

    Scientists carried out a year-long study on 1,200 patients with active, moderate-to-severe rheumatoid arthritis, who have not benefited from or been able to tolerate the side effects of current frontline treatment methotrexate.
    They found Sarilumba improved their condition by up to 20 per cent, according to the Daily Express.
     

    Developed by French drugmaker Sanofi and Regeneron, the new drug works by blocking an inflammation-causing protein called interleukin 6.

    Patients given a 200 mg dose of Sarilumba every other week - on top of methotrexate - saw a 66 percent improvement in the symptoms of rheumatoid arthritis after six months.
    drug
    Developers: The drug has been developed by French drugmaker Sanofi, above, in partnership with Regeneron

    Meanwhile, those given a 150 mg dose saw a 58 percent improvement.
    Reported side effects included infections, as well as increases in 'bad' low-density lipoprotein (LDL) cholestoral and transaminases. 
    Last night, scientists, doctors and charities hailed the drug as a breakthrough in the fight against rheumetoid arthritis.
    A spokesman for the National Rheumatoid Arthritis Society (NRAS) said: 'If this drug gives another option for those living with the disease to lead a fuller and more productive life then this can only be a positive development.'
    'This can only be a positive development'
    NRAS spokesman
    Meanwhile, a spokesman for Arthritis Research UK said: 'The initial results from this trial look quite promising in terms of reducing painful symptoms - although Sarilumab is still under development and results of this study have not yet been published.'
    More than 700,000 people in the UK suffer the agonising effects of rheumatoid arthritis, in which the body's immune system mistakenly attacks healthy tissue, causing inflammation and pain in the joints.
    Although there is currently no cure, numerous treatments are used to alleviate sufferers' pain. 
    Common treatments include anti-inflammatory painkillers and anti-rheumatic drugs, such as methotrexate, which are used to slow joint damage .
    The success of Sarilumba pushes the new drug one step closer to the production line.
    It could be available in 10 years if it is officially approved.


    Read more: http://www.dailymail.co.uk/health/article-2512295/Arthritis-drug-Sarilumab-slows-condition-improves-mobility.html#ixzz2lhP0XyqO 
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